DNA verificationSpecimen Complications

Clinical Evidence of Error

The diagnostic testing cycle can involve 18 different steps;1 patient misidentification, specimen transposition, and foreign cell contamination can occur at multiple steps in the anatomical pathology process. These Specimen Provenance Complications (SPCs) can pose serious patient safety and medical-legal risks.

SPCs can occur outside your controlled laboratory environment even when automation technologies are employed through the Analytic Phase of testing and meticulous operating procedures are followed. Our DNA Specimen Provenance Assignment (DSPA) testing complements your workflow while protecting your laboratory across the entire testing cycle.

In a study published in the American Journal of Clinical Pathology, Washington University confirmed that the average frequency of occult SPCs is 1.9% across all clinical settings.2 In another large multicenter trial (REDUCE, published in the Journal of Clinical Oncology), over 13% of biopsy specimens were found to be contaminated with unidentified DNA while also revealing a sample mismatch rate of 0.4%.3

Specimen Verification

We are now widely offering our DNA Specimen Provenance Assignment (DSPA) Testing to help support physicians across the US and Canada in solving unexpected questions on the misidentified specimens.

• Areas of interest on slides or blocks

• Fragments, floaters in histologic specimens

• Multiple medical samples found within the same specimen jars

• Non-labeled specimen jars or slides

• Indiscriminate medical samples

Your Trusted Partner

An Advocate in Patient & Practice Safety

Let Strand Diagnostics be your trusted partner to provide DNA confirmation when needed for your biopsy specimens. Strand Diagnostics has a long history as a comprehensive provider of identify confirmation testing services, solving complex problems in the criminal justice system (supporting US law enforcement agencies with forensic DNA testing) and our life sciences division utilizing the know error® system. Our DNA testing brings patient safety and diagnostic accuracy throughout the diagnostic testing cycle.

Contact Us

Call us today for fast, reliable results: 888-924-6779, option 2 or email us at clientservices@knowerror.com


1. Bronner MP. DNA fingerprint analysis for specimen identification. Clinical and Translational Pathology Research. Division of Pathology and Laboratory Medicine, Cleveland Clinic. 2006; Fall:5-7.
2. Pfeifer JD, Liu J. Rate of occult specimen provenance complications in routine clinical practice. American Journal of Clinical Pathology. 2013; 139(1):93-100.
3. Marberger, McConnell, Fowler, Andriole, Bostwick, Somerville, & Rittmaster. Biopsy Misidentification Identified by DNA Profiling. Journal of Clinical Oncology. May 1, 2011; Vol.29 No. 13:1744-1749.


 

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